The text of Linda Richter's plenary presentation at the XVII International AIDS Conference in Mexico City on 6 August 2008, which argues that children and families have been severely neglected in our responses to HIV and AIDS. It makes the case that responses should be large-scale, integrated and national, characterized by social justice enabled by basic income security and by universal access to essential services such as health, education and social welfare. PLEASE NOTE: THIS IS A WEB-BASED PUBLICATION ONLY; NO PRINTED COPIES WILL BE PRODUCED.